Search results for "Histidine Metabolism"

showing 2 items of 2 documents

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction

2014

Background & Aims Early allograft dysfunction (EAD) dramatically influences graft and patient outcome after orthotopic liver transplantation and its incidence is strongly determined by donor liver quality. Nevertheless, objective biomarkers, which can assess graft quality and anticipate organ function, are still lacking. This study aims to investigate whether there is a preoperative donor liver metabolomic biosignature associated with EAD. Methods A comprehensive metabolomic profiling of 124 donor liver biopsies collected before transplantation was performed by mass spectrometry coupled to liquid chromatography. Donor liver grafts were classified into two groups: showing EAD and immediate g…

Graft RejectionMalemedicine.medical_specialtyOrthotopic liver transplantationmedicine.drug_classBiopsyHistidine MetabolismGastroenterologyBile Acids and SaltsModel for End-Stage Liver DiseaseMetabolomicsPredictive Value of TestsRisk FactorsInternal medicineLipidomicsmedicineHumansMetabolomicsHistidinePhospholipidsHepatologyBile acidbusiness.industryMiddle AgedAllograftsTissue DonorsLiver TransplantationSphingomyelinsTransplantationLiverBiochemistryFemaleLysophospholipidsbusinessLiving donor liver transplantationBiomarkersJournal of Hepatology
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Monitoring the formation of biosilica catalysed by histidine-tagged silicatein.

2004

Surface bound silicatein retains its biocatalytic activity, which was demonstrated by monitoring the immobilisation of silicatein using a histidine-tag chelating anchor and the subsequent biosilicification of SiO(2) on surfaces by surface plasmon resonance spectroscopy, atomic force microscopy and scanning electron microscopy.

Molecular StructureAtomic force microscopyChemistryMetals and AlloysNanotechnologyGeneral ChemistryHistidine MetabolismSurface Plasmon ResonanceMicroscopy Atomic ForceSilicon DioxideCathepsinsCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsMicroscopyMaterials ChemistryCeramics and CompositesBiophysicsMicroscopy Electron ScanningMoleculeChelationHistidineSurface plasmon resonanceSurface plasmon resonance spectroscopyHistidineChemical communications (Cambridge, England)
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